RCT of home-care and routine cryptococcal meningitis screening among patients starting antiretroviral therapy with advanced disease.

Reduction of early morality among HIV-infected subjects starting antiretroviral therapy in Zambia and Tanzania with CD4 count<100 cells per microlite: a randomised trial involving home support and routine screening for cryptococcal meningitis.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201112000327297

Enrollment

2500

Registered

2011-10-10

Start date

2011-12-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV/AIDS Nervous System Diseases

Interventions

Accelerated initiation of ART, lay adherence support and diagnostic testing for major co-infections

Standard of Care

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: CD418y or more Antiretroviral naive (as reported by the patient) Planning to remain in the study area for about 6 months (as reported by the patient)

Exclusion criteria

Exclusion criteria: Requiring immediate in-patient care/admission Living outside the catchment population of the hospital

Design outcomes

Primary

Measure	Time frame
All-cause mortality	—

Secondary

Measure	Time frame
Costs of the two strategies to the health service;Patient retention on ART;Rate of hospital admission;Frequency of outpatient attendances;Detection of tuberculosis among patients on ART and their household members;Detection of cryptococcal meningitis among patients on ART;Uptake of HIV voluntary counselling and testing and of TB screening among household member;Adherence to ART	—

Countries

Tanzania, Zambia

Contacts

Public ContactSusie Burdett

Research Group Administrator

susanna.burdett@lshtm.ac.uk020 927 2703

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026