The effect of prebiotic supplementation on disease progression and anthropometric status of HIV positive ARV naïve adults attending a wellness program

The effect of prebiotic supplementation on disease progression and anthropometric status of HIV positive ARV naïve adults attending a wellness program in KwaZulu-Natal, South Africa

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201110000331360

Enrollment

200

Registered

2011-10-26

Start date

2012-05-05

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV/AIDS

Interventions

Inulin-type fructans

Placebo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: HIV infected ARV naïve adults Between 18 to 44 years of age CD4+ count of >350 cells/mm3

Exclusion criteria

Exclusion criteria: Pregnant/lactating women Hepatic/renal insufficiency Chronic disease eg cancer, diabetes, cardiac Taking antibiotics for up to 1 month before beginning the trial Under 18 years and over 44 years Postmenopausal women CD4 counts <350 cells/mm3 Taking ARV/HAART Consuming dietary supplements with either pre or probiotics for up to 1 month before beginning the trial

Design outcomes

Primary

Measure	Time frame
To compare changes in microbial translocation by detecting changes in the concentrations of both lipopolysaccharide (LPS) and soluble CD14 (sCD14) in participants in the inulin-type fructans versus placebo group.	—

Secondary

Measure	Time frame
Changes in the incidence of diarrhoea and in quality of life;Changes in anthropometry and fat free mass	—

Countries

South Africa

Contacts

Public ContactChara Biggs

University of KwaZulu Natal

biggsc@ukzn.ac.za+27 33 2606153

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026