NUSTART

Conditions

HIV/AIDS

Susannah Woodd, Paul Kelly, John R. Koethe, George PrayGod, Andrea M. Rehman et al. (10 authors)

BMC Infectious Diseases2016-10-1222 citations

Lipid-based nutrient supplements containing vitamins and minerals attenuate renal electrolyte loss in HIV/AIDS patients starting antiretroviral therapy: A randomized controlled trial in Zambia.

Munkombwe D, Muungo TL, Michelo C, Kelly P, Chirwa S, Filteau S.

2016-04-016 citations

10.1016/j.clnesp.2016.03.002

Effects on mortality of a nutritional intervention for malnourished HIV-infected adults referred for antiretroviral therapy: a randomised controlled trial.

NUSTART (Nutritional Support for Africans Starting Antiretroviral Therapy) Study Team, Filteau S, PrayGod G, Kasonka L, Woodd S, Rehman AM, Chisenga M, Siame J, Koethe JR, Changalucha J, Michael D, Kidola J, Manno D, Larke N, Yilma D, Heimburger DC, Friis H, Kelly P.

2015-01-2838 citations

10.1186/s12916-014-0253-8

Interventions

Micronutrient and mineral supplement

Placebo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: at least 18 years old; ART-naive (except for standard regimens to prevent maternal-to-child HIV transmission); BMI < 18.5 kg/m2. In the presence of clinical oedema and a BMI < 20 kg/m2, BMI will be re-measured after loss of oedema, and the patient considered eligible if BMI < 18.5 kg/m2 and ART has not yet been initiated; requiring ART as determined by CD4 count < 350/ul or stage 3 or 4 disease; willing to undertake intensive ART follow-up in the study clinic; providing written, fully informed consent (thumbprint will be accepted)

Exclusion criteria

Exclusion criteria: participation in a potentially conflicting research protocol; pregnancy (by self-report)

Design outcomes

Primary

Measure	Time frame
Mortality	—

Secondary

Measure	Time frame
Hospitalisation;Any SAE;Weight gain;Appetite;Grip strength;Change in fat-free mass and fat mass ;Plasma electrolytes;Iron status	—

Countries

Tanzania, Zambia

Contacts

Public ContactYolanda Fernandez

Project Administrator

Yolanda.Fernandez@lshtm.ac.uk+44 20 7958 8108

Outcome results

None listed