Graft-versus-host reaction Immune rejection donor-recipient
Conditions
Interventions
No intervention 
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Age = 18 years and scheduled for standard-of-care fresh OCA transplantation of the knee.Willing and able to comply with the extra blood tube at baseline, and blood sampling schedule at 3-month, and 12-month follow-up.Signed written informed consent for participation in the research component of the standard-of-care treatment.
Exclusion criteria
Exclusion criteria: Medical contraindications for blood sampling, such as severe anemia, coagulopathy, or other conditions that make phlebotomy unsafe.Acute systemic infection or inflammatory condition at the time of scheduled blood sampling, which could compromise baseline or follow-up HLA-antibody measurements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the development of donor-specific and HLA-specific antibodies measured by Luminex assays. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include the kinetics of antibody formation, immune cell activation, and their associations with graft characteristics and HLA mismatches between donor and recipient. | — |
Countries
Netherlands
Contacts
Public ContactJ.V. Korpershoek
Universitair Medisch Centrum Utrecht
Outcome results
None listed