psychotic disorders, schizophrenia spectrum disorders, psychosis psychosis, schizophrenia
Conditions
Interventions
None listed
Sponsors
Espria
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Either: Ultra-high-risk for psychosis, as assessed with the Comprehensive Assessment of At-Risk Mental States (CAARMS) no longer than 12 months before inclusion. Or: First episode psychosis (maximally five years in the past), as assessed by a clinician. Participants must report the presence of basic self-disturbances during the initial screening and the Examination of Anomalous Self Experience (EASE) interview (see protocol for details). The individual is currently not acutely psychotic to such a degree that participation is not possible. Participants will be excluded if their psychotic experiences were solely during substance intoxication. Participants will be excluded if their psychotic experiences were solely during substance intoxication.Ability to speak and read the Dutch language. Participants must own a smartphone capable of running m-path.
Exclusion criteria
Exclusion criteria: FEP participants must not have received diagnosis of an affective disorder. Participants must not have received a diagnosis of an intellectual disability or severe developmental disorder. Participants who do not answer yes to one of three main questions or affirm four items from sub-questions during the screening or EASE interview will be excluded from the study. We will also exclude participants who we judge to not fulfil clinical relevance for inclusion (e.g., participants with four items but who give the impression that their experience is non-specific for BSD).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The study’s main parameters are the within-person variability in intensity of basic self-disturbances over time as assessed with the self-report items in the REAL instrument. This will be operationalized by calculating the mean intensity of BSD experiences and measures of intra-individual variability (e.g., within-person standard deviations, mean squared successive differences) across the EMA measurements. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters are dynamic associations (correlations), between-person variability measures, and change over time: (a) contemporaneous correlations among BSD items and between BSD, contextual variables and psychotic symptoms (assessed with contextual ESM items and ESM items from the ESM Repository); (b) lagged (temporal) correlations and directed autoregressive coefficients (e.g., lag-1 effects) among BSD items and between BSD, and context; (c) time trends in mean BSD intensity and within-person means of individual BSD items (group- and individual-level slopes); and (d) the association of baseline BSD (EASE-score) and baseline psychotic symptoms (PANSS-6) with within-person-mean BSD, within-person variability (SD or MSSD) and change over time. | — |
Countries
Netherlands
Contacts
Public ContactG. H. M. Pijnenborg-Nieuwland
Espria
Outcome results
None listed