Research into the role of inflammation in cerebral aneurysms

INSPIRE: INflammation-mediated Sex-specific Pathway elucidation in Intracranial aneurysmal Research - INSPIRE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON61375

Enrollment

Registered

2026-03-27

Start date

2026-09-01

Completion date

Unknown

Last updated

2026-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intracerebral/intracranial aneurysms, aneurysmal subarachnoid hemorrhage brain aneurysms, bleeding around the brain from a ruptured aneurysm

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: being aged 18 years or olderhaving a ruptured or unruptured saccular intracranial aneurysmrequiring endovascular treatment for the intracranial aneurysmprovide signed informed consent

Exclusion criteria

Exclusion criteria: Inability to provide signed informed consent Inability to undergo a 7 Tesla MRI scan (applicable only to patients with an unruptured IA; patients with a ruptured IA will not undergo 7 Tesla MRI)

Design outcomes

Primary

Measure	Time frame
Main parameters in this study are: (1) Genomic parameters of endothelial cells of IA patients: gene expression (transcripts per million) and gene regulation (chromatin accessibility and transcription factor motif enrichment) of inflammatory genes. Additional main parameters for patients with unruptured IAs specifically are: (2) IA hemodynamic 4D MR flow parameters a. mean flux (ml), b. stroke volume (ml per s), c. derived biomechanical parameters including pulsatility index, arterial distensibility (mm Hg-1), wall shear stress (Pa) and oscillatory shear index. These will be determined both in the IA and in the feeding arteries. Main predictors are: sex and rupture status.	—

Measure

Time frame

Main parameters in this study are: (1) Genomic parameters of endothelial cells of IA patients: gene expression (transcripts per million) and gene regulation (chromatin accessibility and transcription factor motif enrichment) of inflammatory genes. Additional main parameters for patients with unruptured IAs specifically are: (2) IA hemodynamic 4D MR flow parameters a. mean flux (ml), b. stroke volume (ml per s), c. derived biomechanical parameters including pulsatility index, arterial distensibility (mm Hg-1), wall shear stress (Pa) and oscillatory shear index. These will be determined both in the IA and in the feeding arteries. Main predictors are: sex and rupture status.

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Countries

Netherlands

Contacts

Public ContactYM Ruigrok

Universitair Medisch Centrum Utrecht

policvz@umcutrecht.nl0887557989

Outcome results