brain health, cardiovascular health brain health, cardiovascular health
Conditions
Interventions
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Men and women, aged between 40-75 years Pre-diabetes: (A1C of 5.7%–6.4%, a fasting plasma glucose (FPG) of 100–125 mg/dL, or a 2-hour oral glucose tolerance test (OGTT) result of 140–199 mg/dL)BMI ³ 25 kg/m2Fasting serum total cholesterol < 8.0 mmol/LSystolic blood pressure < 160 mmHg and diastolic blood pressure < 100 mmHgWillingness to give up being a blood donor from 8 weeks before the start of the study, during the study and for 4 weeks after completion of the study
Exclusion criteria
Exclusion criteria: - Age less than 40 years old or older than 75 years- BMI < 25 kg/m2- Type 1 or type 2 diabetes- habitual consumption of more than 1 avocado/ week - Left-handedness- Fasting serum total cholesterol > 8.0 mmol/L- Current smoker, or smoking cessation < 12 months- Abuse of drugs- More than 3 alcoholic consumptions per day - Use medication to treat blood pressure, lipid or glucose metabolism- Use of an investigational product within another biomedical intervention trial within the previous 1-month- Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis- Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident- Contra-indications for MRI imaging (e.g. pacemaker, surgical clips/material in body, metal splinter in eye, claustrophobia)- Blood donation in the 8 weeks before the start of the study- Difficulties to draw blood
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome parameter of the intervention will be cerebral blood flow (CBF). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include measures for endothelial function (brachial artery flow mediated vasodilation (FMD), carotid artery reactivity (CAR)) and arterial stiffness (pulse wave velocity (PWV), carotid artery distensibility). | — |
Countries
Netherlands
Contacts
Public ContactTCM Adam
Universiteit Maastricht
Outcome results
None listed