Oral cancer Oral cancer
Conditions
Interventions
Prehabilitation by a personalized nutritional treatment including the use of two daily portions of Fortifit Energy® 
combined with moderate to high-intensity personalized physical exercises 3 to 5 weeks before OSCC combined approach resection. The physical exercise program will be supervised three times per week by
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Subject must undergo major combined approach surgery for oral cancerLow skeletal muscle mass (SMM), based on CT or MRI scans of the head and neck area at level C3Karnofsky Performance status >60Able to walk =60 m without a mobility aid18 years or olderSufficient Dutch writing and reading skills
Exclusion criteria
Exclusion criteria: Patients exercising more than in the prescribed physical exercise intervention of this studyFor patients participating in the physical exercise and nutritional intervention: <2 weeks to participate in the study interventionPatients unwilling to undergo a CT scan following the physical exercise and nutritional prehabilitation intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skeletal muscle mass measurement | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical fitness6-minutes walking test (6MWT)Steep Ramp Test (SRT) Physical muscle strengthGrip strength will be assessed by the JAMAR grip strength dynamometer®Lower and upper muscle strength – assessed by microFET® hand held dynamometer according to standardized procedures30s chair stand test, i.e. the number of completed stand ups on the patients’ fastest pace over a 30-second period8-RM testing of the major muscle groups (arms, legs, shoulders and core) Physical activityPhysical activity will be measured using the Activ8 and SQUASH questionnaire: The Activ8 is an accelerometer to measure physical activity objectively The SQUASH is a survey that assesses physical activity in relation to commuting, leisure time, household chores, and activity at work and school. Body compositionFat-Free Mass (FFM) will be calculated with the Kyle equation using Resistance and Reactance at 50kHz measured by Bioelectrical Impedance Analysis (BIA).35Both methods assess body composition by measuring resistance (R) and reactance (Xc) through capacitance of a current through cells. The impedance of the body is largely determined by the low-impedance lean tissues. The Kyle equation showed reasonable validity in patients with HNSCC.36 BIA will be performed at UMC Utrecht using the Bodystat® QuadScan 4000, a multifrequency BIA device. Air Displacement Plethysmography (BODPOD®); whole body density is based on the determination of body mass and body volume. The BODPOD® provides information about the amount of FM and FFM, in percentage and absolute amounts. In the BODPOD®, the system’s electronic scale is used to measure the subject’s mass. Subject’s volume is measured in the BOD POD® by air displacement plethysmography. Once the subject’s mass (Mb) and volume (Vb) are measured, body density (Db) can be calculated as follows: Db = Mb/ Vb. The determination of body composition by densitometry is based on modeling the body into two compartments | — |
Countries
Netherlands
Contacts
Public ContactC.M. Speksnijder
Universitair Medisch Centrum Utrecht
Outcome results
None listed