postprandial glycemic responses Blood sugar response after a meal
Conditions
Interventions
Participants receive twice a full dose of unfiltered apple vinegar, twice a control without vinegar (water only), once the full dose 10 minutes before the carbohydrate-rich meal, and once a diluted sh
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy men and women (self-reported);BMI of =18 – <30 kg/m2;Age of =45 –=75 years;Have a stable body weight (± <3 kg) for at least 1 month prior to enrolment;Willing to maintain a stable lifestyle along the study duration.
Exclusion criteria
Exclusion criteria: Diagnosed diabetes mellitus or a gastrointestinal disorder (among others chronic or recurrent gastric symptoms such as frequent acid reflux, heartburn), that could affect study measures (to be determined by the medical investigator)Having a history of gastrointestinal surgery Use of medication or supplements affecting glucose metabolism (e.g. insulin or metformin) or medication affecting gastrointestinal function (e.g. proton pump inhibitors or H2-receptor antagonists), as well as chronic/long-term NSAIDs use, or prokinetic agents that can affect the study outcomes, to be determined by the medical investigatorAllergy or intolerance to the test meals Participation in another clinical trial Current smoker or having smoked within the last 3 monthsAverage alcohol intake >14 (women) or >21 (men) of alcoholic units per week; Being pregnant or lactating, or willing to be during the study course of the studyPlanning of extreme sports during the studyNot having access to a freezer for storing bread-based meals for a period of up to two weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint: the incremental Area Under the Curve (iAUC) for postprandial glucose response over a 120-minute period following the start of the standardized meal, as measured using a continuous glucose monitor (CGM). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints:Maximum postprandial glucose concentration (Cmax)Time to reach maximum postprandial glucose concentration (Tmax) | — |
Countries
Netherlands
Contacts
Public ContactM Belt
Wageningen Universiteit
Outcome results
None listed