Critical illness intensive care patients
Conditions
Interventions
All patients will undergo an active physiotherapeutic intervention, such as sitting at the edge of the bed, standing, or walking. 
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Patients over 18 years of age who have been ventilated in the ICU for more than 48 hours, have no neurological diagnosis and had an order for physical therapy during the ICU admission.Patients who are competent to provide consentPatients meet the safety criteria for active physical therapy
Exclusion criteria
Exclusion criteria: Patients with neurological disorder as primary reason for admission to the ICU (ie, subarachnoid bleeding, stroke, traumatic brain injury, neuro muscular disease) were not screened for eligibility. Exclusion criteria included contraindications to perform physical exercise safely according to the criteria of the Evidence Statement for physical therapy in the ICU, unable to follow instructions (measured with the Standardized 5 Questions)Recent myocardial ischemiaHart frequency <40 or > 130 /mBlood pressure: Map <60 mmHg or >110 mmHg Pulse oxymetry: = 90% Mechanical ventilation: FiO2 =0.6 (60%) PEEP= 10cm H2O Breathing frequency: Frequency > 40 per minute Level of consciousness : RASS score: -4, -5, 3 or 4 Dose of inotropes: Dopamine > 10 mcg/kg/min Nor/adrenaline = 0.1 mcg/kg/min Temperature: = 38.5 degrees Celsius=36 degrees Other: Pain, fatigue Surgical contra-indications (i.e. instable fractures, bone flap, open abdomen or thorax) Insufficient knowledge of the Dutch language, One or more amputated lower extremities, People unable to consent/ incapacitated peopleCooperative of S5Q < 3 from the Standardized 5 Questions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Can mitochondrial oxygen pressure (mitoPO2) and oxygen consumption (mitoVO2) be used as a marker for exercise tolerance during active rehabilitation in critically ill patients.To explore whether MitoPO2 and MitoVO2 can serve as an early marker for overexertion as indicated by a decrease in MitoPO2 and MitoVO2 occurring before lactate rises, enabling early detection of overexertion. | — |
Secondary
| Measure | Time frame |
|---|---|
| To investigate risk factors for exercise intoleranceIs the baseline value of in MitoPO2 and MitoVO2 predictive of readiness tolerance? Is over-exercise associated with a dissociation between MitoPO2 and MitoVO2?Does a specific level of inflammatory parameters correlate with lactate, MitoPO2, and MitoVO2?How do MitoPO2 and MitoVO2 correlate between rest and exercise, and how do they compare with other parameters used to measure exercise?Parameters: Blood pressure, heartrate, breathing frequency, cardiac output, oxygen saturation, shunt fraction, PO2, PCO2, PH | — |
Countries
Netherlands
Contacts
Public ContactN.P Juffermans
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed