narcosis and sleepmedication narcosis and sleepmedication
Conditions
Interventions
The Eleveld PKPD model. The Eleveld PKPD model predicts the initial dose and infusion rate of remimazolam for maintaining general anaesthesia and sedation, based on general parameters such as height,
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age = 18 yearsAmerican Society of Anesthesiologists (ASA) physical status 1-3Elective surgical procedure of >1 hour expected durationNeed for an arterial line placement for the procedureWritten informed consent
Exclusion criteria
Exclusion criteria: Contraindication for the use of remimazolam (e.g. allergy, unstable myasthenia gravis, or pregnancy)Inclusion in other studies preventing the use of remimazolam as primary hypnotic agentPatients taking other sedatives/hypnotics prior to administration of remimazolamPatients who have been admitted to the intensive care unit prior to surgery and/or have received remimazolam as sedation or anaesthesia in the 24 hours before the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Performance criteria (performance error, median (absolute) performance error, divergence, wobble) assessing the performance of the Eleveld PKPD model in the studied population. | — |
Countries
Netherlands
Contacts
Public ContactM.M.R.F. Struys
Universitair Medisch Centrum Groningen
Outcome results
None listed