(ipsilateral) motor function brain activity during movements
Conditions
Interventions
Real and sham cTBS applied to contralateral M1 prior to fMRI scanning.
Of note: 
cTBS is used solely as a research tool to transiently modulate cortical excitability in healthy volunteers. It is not applied with therapeutic intent and does not aim to provide clinical benefit.
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Blank neurological history Aged between 18 – 65 years Ability to provide informed consent Right-handedness
Exclusion criteria
Exclusion criteria: Noncompliance with the MRI safety checklist Anxiety in the scanner/claustrophobia Pregnancy Inability to hear the instructions presented orally in the scanner without a hearing aid Inability to clearly see the visual stimuli presented in the scanner without glassesMagnetic sensitive objects implanted in the head or neck area (e.g., cochlear implants, implanted neurostimulator, pacemaker or defibrillator, metal splinters, metal fragments, or metal clips)History of epilepsy or seizure disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in the amplitude of the BOLD signal in ipsilateral M1 between real and sham inhibitory stimulation of contralateral M1. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the decodability of the BOLD signal in ipsilateral M1 between real and sham inhibitory stimulation of contralateral M1. and the decodability of hand movementsDifference in behavioural performance (e.g., onset times, speed, accuracy, mirror movements) during the hand movement task in response to cTBS vs sham. Validation that the cTBS stimulation was successful by measuring MEPs in response to single-pulse TMS right after cTBS. | — |
Countries
Netherlands
Contacts
Public ContactN.F. Ramsey
Universitair Medisch Centrum Utrecht
Outcome results
None listed