Socioeconomic position, Air Pollution, and Immunity in Older adults (SAPIO)

Identifying mucosal and systemic immune alterations associated with socioeconomic position and air pollution: mechanisms underlying susceptibility to respiratory tract infections in older adults. - Socioeconomic position, Air Pollution, and Immunity in Older adults (SAPIO)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON61268

Enrollment

200

Registered

2026-03-10

Start date

2026-07-01

Completion date

Unknown

Last updated

2026-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory tract infections Chest infections / Respiratory tract infections

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Between 60 and 80 years of age Able and willing to provide informed consent.Resides and is registered at an address in one of the four SEP-pollution strata neighbourhoods (Vogelwijk, Bezuidenhout, Duindorp, Schilderswijk)

Exclusion criteria

Exclusion criteria: Incompetence to provide informed consent before or during the studyRecent or recurrent nosebleeds.Immunocompromised individuals (with primary immune deficiency or secondary immune deficiency)Individuals who plan to be away from their primary residence for more than six weeks in the follow-up period (October – May)If participants have rhinitis/RTI symptoms or known acute infection, the intake meeting will be delayed for a minimum of 14 days after clearance of all symptoms. 

Design outcomes

Primary

Measure	Time frame
Frequency of nasal CD4+ and CD8+ T cells in older adults stratified by SEP-pollution stratified neighbourhood (Vogelwijk, Schilderswijk, Bezuidenhout, Duindorp).	—

Secondary

Measure	Time frame
Phenotype (subsets, activation status), functionality, transcriptomic state, clonality and frequency of nasal and blood cell in older adults between SEP-pollution stratified neighbourhoods before the respiratory season Age, sex, living environment, SEP, chronic stress, frailty, comorbidity, metabolomics-based biomarkers of overall health (e.g. Personal-MetaboHealth), and other immunologically relevant parameters association with T cell frequency and other immune parametersAssociation between the concentration of nasal and systemic factors (e.g. cytokines and metabolites), immune populations, SEP-pollution stratified neighbourhoods and covariates, at baseline. RTI incidence per SEP-pollution stratified neighbourhood.Association between baseline immune profiles and subsequent RTI incidenceNasal immune responses associated with RTIRespiratory tract microbiota profiles by SEP-pollution stratified neighbourhood and their association with immune parameters Comparison of immune responses and infections against other cohorts and public datasets with nasal and/or blood immune analysis.In vitro immune responses and infection levels in nasal derived organoids associated with RTI and stratified by SEP-pollution stratified neighbourhood	—

Measure

Time frame

Phenotype (subsets, activation status), functionality, transcriptomic state, clonality and frequency of nasal and blood cell in older adults between SEP-pollution stratified neighbourhoods before the respiratory season Age, sex, living environment, SEP, chronic stress, frailty, comorbidity, metabolomics-based biomarkers of overall health (e.g. Personal-MetaboHealth), and other immunologically relevant parameters association with T cell frequency and other immune parametersAssociation between the concentration of nasal and systemic factors (e.g. cytokines and metabolites), immune populations, SEP-pollution stratified neighbourhoods and covariates, at baseline. RTI incidence per SEP-pollution stratified neighbourhood.Association between baseline immune profiles and subsequent RTI incidenceNasal immune responses associated with RTIRespiratory tract microbiota profiles by SEP-pollution stratified neighbourhood and their association with immune parameters Comparison of immune responses and infections against other cohorts and public datasets with nasal and/or blood immune analysis.In vitro immune responses and infection levels in nasal derived organoids associated with RTI and stratified by SEP-pollution stratified neighbourhood

—

Countries

Netherlands

Contacts

Public ContactH. Borgdorff

Leids Universitair Medisch Centrum

h.borgdorff@lumc.nl0615672748

Outcome results