Kidney transplant recipients with reduced kidney function People with a kidney transplant whose kidney function is reduced
Conditions
Interventions
A 4-week benzoic acid–reduced diet, based on established benzoate-free dietary protocols described in the literature, optimized with the nutrition team of the UMCG to maintain stable vitamin C intake.
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a participant must meet all of the following criteria:Patients older than 18 years=1 year after kidney transplantationeGFR =20 and =60 mL/min/1.73m²The participant consumes products rich in benzoic acid (such as soft drinks, processed foods, and flavoured products) at least 3 times per week.
Exclusion criteria
Exclusion criteria: A potential participant who meets any of the following criteria will be excluded from participation in this study:Patients who are unable to comprehend the instructions of the nutrition team, the questionnaires, and testsUnable or unwilling to adhere to the dietary recommendations of the study protocol Patients following a specific dietary pattern (vegetarian, vegan, paleo)Urinary protein excretion >1gr/24 hoursLife expectancy =1 year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure of the trial is the urinary trans,trans-muconic acid (ttMA) excretion, a biomarker of benzene exposure, measured three times during each 4-week intervention or control period. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include change in plasma vitamin C concentration, quality of life, plasma creatinine concentration; haemoglobin concentration; total white blood cell count; C-reactive proteine; plasma malondialdehyde concentration; and gut microbiome composition. Adherence will be evaluated using a 24-hour dietary recall with calculation of benzoate and vitamin C intake | — |
Countries
Netherlands
Contacts
Public ContactM Yepes Calderon
Universitair Medisch Centrum Groningen
Outcome results
None listed