Normal brain function Normal brain function
Conditions
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Between 18-40 years of age;Have the ability and agreement to provide informed consent in sound body and mind, and the ability to fulfil the study’s requirements.
Exclusion criteria
Exclusion criteria: You may not participate if any of the following points apply to you:Current or planned pregnancy; A history of serious head trauma or brain surgery;Having a cardiac pacemaker or intracardiac lines;Having an implanted neuro-stimulator;Having a cochlear implant;Having an implanted medication infusion device;Implanted metal devices or large ferromagnetic fragments in the head or upper body (excluding dental wire), or jewellery/piercing that cannot be removed;Use of a medical plaster that cannot or may not be taken off (e.g., nicotine plaster);Any current episodes of psychiatric or neurological disorders;Claustrophobia;Hearing problems or ringing in the ears;Suffer from epilepsy;Predisposition for fainting spells (syncope); Use of (prescription) medication interacting with neuromodulation;Skin disease or sensitivity at intended stimulation sites;Meet a minimum performance level on the task;Large calcifications in the acoustic focus or beam path. Further, it is important that you:Do not use recreational drugs in the 48 hours prior to participation;Do not consume more than four alcoholic units in the 24 hours prior to participation or any alcoholic units 6 hours prior to participation;Do not consume more than your typical intake of caffeine and nicotine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| During the task, participants' responses will control a joystick whosemovements will be recorded. These behavioural responses will be categorisedbased on in-session conditions and between-session stimulation conditions. Thisallows us to compare the difference in behavioural responses between each condition. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cortical changes in oxygen usage will be mapped using fMRI during task performance. With this, we can map oxygen usage in brain areas including the ones that were shown to be involved by previous studies such as the Amygdala, dACC. This activity can then be related to between-session stimulation conditions and within-session task conditions.In addition to this, we will also use measures of autonomic arousal during the sessions such as respiratory activity, heart rate and electrodermal activity. | — |
Countries
Netherlands
Contacts
Public ContactK.T. Zee
Radboud Universiteit Nijmegen
Outcome results
None listed