Peripheral artery disease (PAD) Blockage of leg arteries
Conditions
Interventions
All participants will undergo controlled modulation of foot skin temperature within a clinically feasible range (26-31°C). Microcirculatory measurements (TcPO2, LSCI and SPP) will be performed under t
Sponsors
Ziekenhuis Groep Twente (ZGT)
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: >18 yearsWilling to give written informed consent (IC) PAD stage Fontaine 2 (2a or 2b)
Exclusion criteria
Exclusion criteria: Amputation of (part of) the lower extremitiesPresence of wounds or other skin lesions on the foot (e.g. ulcers, blisters, or other forms of skin damage)Severe callusSevere cold sensitivity (e.g. Raynaud’s syndrome)Oedema or infection of (part of) the lower extremitiesSevere or unstable heart failure (NYHA class III–IV or recent decompensation)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameters are the within-subject differences and between-subject variability in TcPO2, LSCI, and SPP measurements, measured under cold and warm conditions. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameters are the within-subject differences and between-subject variability in TcPO2, LSCI, and SPP measurements in the subgroups with and without peripheral neuropathy and with and without diabetes. | — |
Countries
Netherlands
Contacts
Public ContactK.D.R. Kappert
Ziekenhuis Groep Twente (ZGT)
Outcome results
None listed