Pumping capacity of the heart during exercise.

Multi-Scale Systems Analysis of Metabolic and Mechanical Determinants of Reserve Cardiac Power Output - POWER

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON61141

Enrollment

100

Registered

2025-07-22

Start date

2026-04-01

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Heart failure Heart failure

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with suspected or confirmed heart failure (n = 40)Suspected or confirmed heart failure with a clinical indication for right heart catheterization: NYHA class II-IV. Clinically stable comorbidities. Able and willing to provide written informed consent. Healthy individuals (n = 60)Aged within one of three age-groups Young adults (10 male/10 female): aged between 20 – 40 years.Middle-aged adults (10 male/10 female): aged between 40 – 60 years.Healthy older adults (10 male/10 female): aged between 60 – 80 years.No history of cardiovascular disease. Able and willing to provide written informed consent.

Exclusion criteria

Exclusion criteria: Patients with suspected or confirmed HF Contraindications (including all pacemakers and implantable cardioverter-defibrillators (ICDs)) or refusal of MR imaging.Cardiac amyloidosis or other infiltrative cardiomyopathy, cardiac storage disease, significant congenital and other structural heart disease.Current acute decompensated heart failure.Presence of uncontrolled atrial fibrillation with resting heart rate >110 beats/min.Acute coronary syndrome, TIA/CVA, major surgery within the 3 months prior.History of myocardial infarction.Other significant cardiac (e.g. significant valvular disease) or extra-cardiac condition (e.g. severe chronic obstructive pulmonary disease; COPD) that explains symptoms.Presence of other disabling co-morbidities that might hamper or endanger physical exercise e.g. orthopedic conditions or neurological disorders.Pregnancy. Healthy individuals Contraindications or refusal of MR imaging.History of cardiovascular disease.Presence of disabling co-morbidities that might hamper or endanger physical exercise e.g. chronic obstructive pulmonary disease, orthopedic conditions or neurological disorders.Pregnancy. 

Design outcomes

Primary

Measure	Time frame
The main study parameters will be myocardial metabolic energy status and aerobic capacity.	—

Secondary

Measure	Time frame
Secondary, cardiac mechanical function, pulmonary hemodynamics (HF only), skeletal muscle energetics, and blood pressure response to the Valsalva maneuver, will be assessed.	—

Countries

Netherlands

Contacts

Public ContactI.H. Mast

Amsterdam UMC

i.mast@amsterdamumc.nl020-5668325

Outcome results