Amino acid absorption, satiety regulation Effects of protein type and minerals on amino acid availability
Conditions
Interventions
25 g whey protein isolate25 g calcium caseinate25 g sodium caseinate25 g magnesium caseinate25 g potassium caseinate
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: To be eligible to participate in this study, a participant must meet all of the following criteria:Male or female sexAged between 18 – 35 years inclusiveBMI between 18 – 30 kg/m2Healthy, recreationally active (exercise at least once per two weeks and a maximum of four days per week)No physical limitations (i.e., able to perform all activities associated with daily living independently)
Exclusion criteria
Exclusion criteria: A potential participant who meets any of the following criteria will be excluded from participation in this study:Intolerant to milk protein and/or dairy-based productsSmoking regularlyDiagnosed with gastro-intestinal disordersDiagnosed with metabolic disorders (e.g. diabetes)Diagnosed with musculoskeletal disordersBlood donation in the past 2 monthsFemales: pregnancyUse of any medication known to affect protein metabolism (e.g. corticosteroids, non-steroidal anti-inflammatories or prescribed acne medications)Chronic use of gastric acid suppressing drugs (e.g. proton pump inhibitors, H2-antagonists)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of this study is to compare the 6-hour postprandial plasma total amino acid availability, expressed as incremental area under the curve (iAUC), following ingestion of different protein isolates in healthy young adults | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objectives for both sub-studies are: To compare plasma concentrations of non-essential amino acids, essential amino acids, branched-chain amino acids.To compare 6h postprandial serum mineral (calcium, magnesium, sodium, potassium) and parathyroid (PTH) concentrations (as a proxy of calcium bioavailability).To compare 6h postprandial plasma GLP-1, osmolality, and fibroblast-growth-factor 21 (FGF-21) responses. | — |
Countries
Netherlands
Contacts
Public ContactN. Boot
Universiteit Maastricht
Outcome results
None listed