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ENYOY: the next steps

ENgage YOung people earlY: the next steps - ENYOY: the next steps

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
NL-OMON
Registry ID
NL-OMON58587
Enrollment
337
Registered
2025-09-23
Start date
2026-06-21
Completion date
Unknown
Last updated
2026-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stress, anxiety, psychological distress, low mood, psychological complaints, mental health problems, lower mental well-being, reduced quality of life, decreased social and occupational functioning, and lower self-confidence. Stress, worrying, feeling sad or down, having trouble with your thoughts or feelings, not feeling good about yourself, enjoying life less, having difficulties at school, work, or with other people, and feeling less confident.

Interventions

The ENYOY platform offers guided therapy journeys, professional support (by mental health moderators and youth with lived experience of mental ill-health), and a moderated online peer-to-peer communit

Sponsors

Amsterdam UMC
Lead Sponsor

Eligibility

Age
16 Years to 64 Years

Inclusion criteria

Inclusion criteria: Age 16-25Help seeking (e.g., attending local mental health services or seeking help for psychological distress; health service; university student counselling)Able and willing to consent; parental consent when applicable A score of 10 or higher on the CORE-10 questionnaireHave personal and private access to a computer, smartphone or tablet.  Ability and willingness to nominate an emergency contact person, such as a close family member.

Exclusion criteria

Exclusion criteria: Insufficient command of the local language at the study center (i.e. Dutch).Present with acute suicidal behavior or imminent risk of harm to self.If their psychiatric symptoms are due to an organic cause.Prior exposure to ENYOY intervention. 

Design outcomes

Primary

MeasureTime frame
The primary endpoint is psychological distress measured with the CORE-10 total score at 3-month follow-up. 

Secondary

MeasureTime frame
The secondary study parameters are social functioning (WSAS), depression (PHQ-9) and anxiety symptoms (GAD-7), self-esteem (RSES) and quality of life (EQ-5D-5L & MLT). Additionally, the cost-effectiveness of ENYOY will be evaluated, along with its public health impact and sustainability, using the RE-AIM framework. Furthermore, aspects related to implementation, ethical considerations, and platform safety will also be assessed.

Countries

Netherlands

Contacts

Public ContactF Hellegers

Amsterdam UMC

f.hellegers@amsterdamumc.nl+31627326769

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Aug 25, 2026