Angina with non-obstructive coronary arteries (ANOCA), non-obstructive coronary artery disease (NOCAD), ischemia with non-obstructive coronary arteries (INOCA). Coronary vasomotor dysfunction (CVDys)
Conditions
Interventions
170 ANOCA patients will be 1:1 randomised to either routine CFT or selective CFT. In the routine CFT arm, patients will be scheduled for CFT within four weeks after inclusion, and treatment will be ta
In the case of invalidating and/or intolerable symptoms, the treating cardiologist may decide to perform CFT earlier than six months after presentation. 
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: At least 18 years of ageAnginal pain and non-obstructive coronary arteries on coronary CT scanAble to complete Dutch questionnairesWritten informed consent
Exclusion criteria
Exclusion criteria: Limited life expectancy (Active desire for) pregnancyOther cause of angina than CVDys highly likelyCertain cardiac history (myocardial infarction, CABG, PCI, heart failure, valvular heart disease), severe renal dysfunctionContra-indication to CFT
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is angina-related quality of life at 6-month follow-up quantified by the within-subject change in the Seattle Angina Questionnaire summary score (SAQSS). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include anginal complaints at 6-month follow-up, quality of life at 3- and 6-month follow-up, and the proportion of patients whose symptoms have resolved and whose anti-anginal medication has been discontinued at 3- and 6-month follow-up. | — |
Countries
Netherlands
Contacts
Public ContactF.W. Adriaansen
Radboud Universitair Medisch Centrum
Outcome results
None listed