SSR in DEE-SWAS

Sleep spindle rate (SSR) as an alternative to spike-wave index (SWI) for cognitive impairment prediction in patients with Developmental and/or epileptic encephalopathy with spike-wave activation in sleep (DEE-SWAS) - Sleep spindles DEE-SWAS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON58577

Enrollment

Registered

2026-03-11

Start date

2026-01-19

Completion date

Unknown

Last updated

2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Developmental and/or epileptic encephalopathy with spike-wave activation in sleep (DEE-SWAS), Electrical Status Epilepticus in Sleep (ESES), Continuous Spike-Waves during Slow-Wave Sleep (CSWS) Frequent epileptiform activity during sleep

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: - The diagnosis of DEE-SWAS has been definitively established at some point; this includes children for whom the diagnosis was established prior to the examinations performed within SEIN. - A suspicion of DEE-SWAS by a pediatric neurologist at SEIN is reflected in a referral to the Clinical Neurophysiology and/or Psychology department. - A Clinical Neurophysiology consent form for retrospective EEG data analysis is already available or is being obtained, including additional consent being obtained for the use of the Neuropsychological data.

Exclusion criteria

Exclusion criteria: - Patients older than 18 years at the time of the EEG/Neuropsychological examinations - Children with Landau-Kleffner syndrome (specific subgroup of children with DEE-SWAS, in whom language function is primarily affected).

Design outcomes

Primary

Measure	Time frame
- NPA: IQ - EEG: SWI, SSR	—

Secondary

Measure	Time frame
- NPA: verbal memory (15WT), questionnaire survey completed by parents and school (CBCL en TRF) - EEG: sleep spindle duration	—

Countries

Netherlands

Contacts

Public ContactT Hal

Stichting Epilepsie Instellingen Nederland (SEIN)

tvhal@sein.nl+31 23 558 89 74

Outcome results