Alzheimer's Disease, Alzheimer's Dementia, Mild Cognitive Impairment, Subjective Cognitive Impairment, AD, MCI, SCI, Cognitive Disorder Alzheimer's Disease, Alzheimer's Dementia
Conditions
Interventions
Already obtained 3 Tesla MRI-scans (MRI-CWK or MRI-Neck combined with MRI-Brain).
Sponsors
Maastricht Universitair Medisch Centrum +
Eligibility
Inclusion criteria
Inclusion criteria: Previously acquired 3T brain MRI in combination with MRI of the neck and/or cervical spine (C-spine)Age >18 yearsClinically diagnosed Alzheimer’s disease, Mild Cognitive Impairment, Subjective Cognitive Impairment, or healthy control subjects
Exclusion criteria
Exclusion criteria: Known systemic lymph node diseaseAnother established neurodegenerative disorder, including: Parkinson’s disease, Huntington’s disease, Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Frontotemporal dementia, Lewy body dementia, or Vascular dementiaPresence of a structural neurological abnormality, including: acquired brain injury or an ischemic/hemorrhagic strokeHistory of radiation therapy or unilateral or bilateral lymph node dissection in the head and neck region
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome measures:Number of lymph nodes: per Robbins level (I–V)Volume: xyz in mm = volume in mm³, with 2.5 mm as the minimum for inclusionShape: round/oval, cortex-to-medulla ratio, presence/absence of fatty hilumSignal intensity: SUV value | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures:Radiological parameters: MTA, CGA, Fazekas, KoemanVariables: age at time of MRI, sex, disease duration, vascular disease (hypertension, type 1 and type 2 diabetes mellitus). | — |
Countries
Netherlands
Contacts
Public ContactB.F.M. Rijken
Maastricht Universitair Medisch Centrum +
Outcome results
None listed