female reproductive health, menstrual health, fertility female health, period, reproduction
Conditions
Interventions
This is an observational, cross-sectional study without an intervention. Study procedures include the collection of patient-reported menstrual health outcomes through questionnaires and the assessment
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
12 Years to 64 Years
Inclusion criteria
Inclusion criteria: The subject is included in the PROactive or WHISTLER cohort and has given consent to be approached for future research purposes. The subject is of the female sex.The subject is aged =12 years old and <25 years old at the time of inclusion.
Exclusion criteria
Exclusion criteria: Known chromosomal or genetic syndromes directly affecting gonadal function (e.g., Turner syndrome, Klinefelter syndrome, disorders of sex development).Current pregnancy.Prior gonadotoxic treatment unrelated to the chronic condition under study (e.g., chemotherapy or radiotherapy for malignancy outside the context of the disease groups included in PROactive).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is menstrual health, evaluated through patient-reported outcomes including age at menarche, cycle regularity, presence and severity of dysmenorrhea, menstrual blood loss, influence of menstrual symptoms on psychological wellbeing and daily life, and contraceptive use. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objectives address ovarian reserve, assessed through serum AMH levels obtained via venous blood sampling. | — |
Countries
Netherlands
Contacts
Public ContactD.E. Bruil
Universitair Medisch Centrum Utrecht
Outcome results
None listed