Spinocerebellar ataxia SCA
Conditions
Interventions
None listed
Sponsors
Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW)
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: For ataxia patients:Clinical diagnosis of spinocerebellar ataxia (SCA6, SCA3, or SCA27b)Age between 18–75 yearsFor healthy controls:No history of neurological or psychiatric disordersAge and sex matched to the patient group
Exclusion criteria
Exclusion criteria: PregnancyGeneral contraindications for MRI: presence of metal implants or other MRI contraindications (e.g., pacemaker, aneurysm clips)Severe claustrophobia or inability to remain still during scanningAdditional exclusion criteria for ataxia patients:Acute medical conditions that could interfere with MRI or study proceduresInability to comply with study requirementsOther neurological disorder, or another disease that significantly influences gait
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphological and microstructural imaging markers (e.g., regional cerebellar volume, cortical thickness and gyrification, diffusion metrics, and functional connectivity). | — |
Secondary
| Measure | Time frame |
|---|---|
| Feasibility of the imaging protocol in ataxia patients, regional comparison of imaging markers between groups. | — |
Countries
Netherlands
Contacts
Public ContactW van der Zwaag
Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences (KNAW)
Outcome results
None listed