acute ischemic stroke stroke
Conditions
Interventions
none
Sponsors
Calgary, Canada
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Large vessel occlusion in the anterior circulation (terminal internal carotid artery, M1 segment or proximal M2 segment middle cerebral artery occlusion) Intention to treat with EVT No contraindications to MRI Adult patients (age 18 years or older)
Exclusion criteria
Exclusion criteria: Contraindications to MRI (eg, incompatible pacemaker or other implants, sever renal failure) Inability to complete 90-day follow up (eg, institutionalized in a nursing home) Expected life expectancy <90 days (patient unlikely to survive until 90 day follow up) Known pregnancy (in women of childbearing potential, a negative blood or urine betaHCG pregnancy test is required prior to enrolment)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary clinical outcome is mRS at 90 days. The primary imaging outcome is infarct volume at 90 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary clinical outcomes are 90 day NIHSS, 365 day mRS (if available), 90 day Barthel Index, 90 day and 365 day (if available) Lawton iADL, cognitive outcomes (MoCA score) at 90 days and health-related quality of life (EQ-5D) at 90 days and 365 days (if available). Secondary imaging outcomes are infarct growth at each time MRI imaging time point (eg, 24h infarct growth, defined as 24h infarct volume minus baseline infarct volume, day 5 infarct growth, defined as day 5 minus baseline infarct growth), perfusion impairment, blood brain barrier breakdown, hemorrhage, brain edema, necrosis, brain atrophy. | — |
Countries
Austria, Canada, France, Germany, Hungary, Japan, Netherlands, Norway, Portugal, South Korea, United Kingdom
Contacts
Public ContactN. Vos van Avezathe
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed