The (cost-)effectiveness of early intervention (MBT-early) versus standard protocolized treatment (CBT) for emerging borderline personality disorder in adolescents: a randomized controlled trial

The (cost-)effectiveness of early intervention (MBT-early) versus standard protocolized treatment (CBT) for emerging borderline personality disorder in adolescents: a randomized controlled trial - The (cost-)effectiveness of MBT-early

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON58552

Enrollment

Registered

2021-03-24

Start date

2021-08-12

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

borderline personality disorder

Interventions

CBT is the standard intervention for young people with mood and/or anxiety disorders in the Netherlands. CBT is a protocolized, time-limited, individual intervention, which may be accompanied by sup

Eligibility

Age

12 Years to 17 Years

Inclusion criteria

Inclusion criteria: Exclusion criteria are: a) presence of a primary diagnosis that requires other specialist treatment (e.g. autism spectrum disorder, chronic psychotic disorder, severe eating disorder of sever substance abuse disorder), b) IQ < 75, c) severe disability with regard to functioning in school, at home and in the peer group representative for later stage BPD. 

Exclusion criteria

Exclusion criteria: Inclusion criteria are: a) age between 12 and 18 years, b) either mood and/or anxiety disorder(s) as assessed by the Structured Clinical Interview for DSM-5 Syndrome Disorders (SCID-5-S; Arntz, Kamphuis, & Derks, 2018), c) 3 to 6 traits of borderline personality disorder using the Structured Clinical Interview for DSM-5 Personality Disorders (SCID-5-PD; Arntz, Kamphuis, & Derks, 2017).

Design outcomes

Primary

Measure	Time frame
The primary outcome variable is the severity of BPD symptoms as assessed using the Borderline Personality Disorder Symptom Severity Index for Adolescents (BPDSI-IV-ado).	—

Secondary

Measure	Time frame
1) Severity of personality functioning (Level of Personality Functioning Scale - Brief Form, version 2.0; LPFS-BF 2.0 and Columbia Suicide Severity Rating Scale; C-SSRS) 2) Severity of symptoms of depression and anxiety (Patient Health Questionnaire; PHQ, Generalized Anxiety Disorder scale; GAD-7 and Brief Symptom Inventory; BSI) 3) Functional outcomes (World Health Organization Disability Assessment Scale; WHODAS 2.0, KIDSCREEN-10, EQ-5D-5L, Network of Relationships Inventory-Behavioral Systems Version; NRI-BSV 4) Economic evaluation (Trimbos/iMTA questionnaire for Costs associated with Psychiatric Disorders; TiC-P)	—

Measure

Time frame

1) Severity of personality functioning (Level of Personality Functioning Scale - Brief Form, version 2.0; LPFS-BF 2.0 and Columbia Suicide Severity Rating Scale; C-SSRS) 2) Severity of symptoms of depression and anxiety (Patient Health Questionnaire; PHQ, Generalized Anxiety Disorder scale; GAD-7 and Brief Symptom Inventory; BSI) 3) Functional outcomes (World Health Organization Disability Assessment Scale; WHODAS 2.0, KIDSCREEN-10, EQ-5D-5L, Network of Relationships Inventory-Behavioral Systems Version; NRI-BSV 4) Economic evaluation (Trimbos/iMTA questionnaire for Costs associated with Psychiatric Disorders; TiC-P)

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Countries

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: May 1, 2026