Sepsis blood poisoning
Conditions
Interventions
Patients in the intervention group will receive 48 hours of external warming with a temperature management system (Artic Sun) to a goal core temperature 1.5°C greater than the lowest recorded temperat
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: >18 years of age• Within 48 hours of sepsis (defined as the date/time of the first order for antibiotics)• Requirement for mechanical ventilation• Maximum temperature < 38.3°C within the 24 hours prior to enrollment. * Meeting the SEPSIS-3 definition for sepsis: suspected or confirmed infection and an acute increase in the Sequential Organ Failure Assessment (SOFA) score by =2 points, indicating organ dysfunction.
Exclusion criteria
Exclusion criteria: Patients with immunologic diseases:HIVneutropeniahistory of chronic infection with hepatitis B or C virusPatients using immune suppressing medications:treatment with corticosteroids at a dose of > 300 mg/day hydrocortisone or equivalent at the time of enrollment; TacrolimusMMFCiclofosfamide Patients with a contraindication for therapeutic hyperthermia: cardiac arrestacute ischemic strokeacute coronary syndrometraumatic brain injuryspinal cord injury sickle cell diseasemultiple sclerosisPregnancyMoribund patients (expected death within 48 hours)Contraindications to forced air warming devices per manufacture instructions (i.e. ischemic limbs)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exploratory proteomics analysis | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical endpoints, macro and microhemodynamic measurements | — |
Countries
Netherlands
Contacts
Public ContactN. Juffermans
Erasmus Universiteit Rotterdam
Outcome results
None listed