Platelet rich plasma Platelet rich plasma
Conditions
Interventions
Participants undergo a single venous blood draw to process approximately 157 mL of blood/citrate at Goed Medisch Centrum (Breda), performed by qualified medical personnel according to standard clinica
Sponsors
Matritech B.V.
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: A subject is eligible to participate in this study if all of the following criteria are met:Age between 18 and 60 yearsAbility to understand the study procedures and provide written informed consentGeneral good health based on medical history and screening questionnaireWillingness to undergo a single venous blood draw of 157 ml
Exclusion criteria
Exclusion criteria: A subject will be excluded from participation if any of the following criteria apply:Age <18 years or >60 yearsPregnancy or breastfeedingKnown anemia, hematological disorder, or bleeding disorderUse of anticoagulant or antiplatelet medicationActive infection or fever at the time of blood donationKnown history of severe vasovagal reactions to blood samplingAny medical condition that, in the opinion of the investigator, may increase the risk of participation or interfere with study procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantitative concentration and time-dependent release profiles of predefined growth factors and cytokines from PRP-loaded ECM hydrogel, measured by multiplex immunoassay (Luminex). | — |
Secondary
| Measure | Time frame |
|---|---|
| Exploratory proteomic characterization of releasate composition.Functional bioactivity of releasates in predefined in vitro biological assays and animal in vivo experiments. | — |
Countries
Netherlands
Contacts
Public ContactJ.A. Dongen
Goed Medisch Centrum
Outcome results
None listed