protein metabolism protein metabolism
Conditions
Interventions
All subjects will undergo a standardized deuterated water dosing protocol for three days prior to their elective surgery.
Sponsors
Universiteit Maastricht
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria adults= 18 years oldPlanned surgery that includes the (partial) resection of organ tissue(s)18.5 = BMI = 35 kg/m2Written informed consent Inclusion criteria children= 8 years old and = 14 years oldPlanned surgery that includes the (partial) resection of organ tissue(s)14 = BMI = 35 kg/m2Written informed consent by parents (and child, in case of age 12-14 years old)
Exclusion criteria
Exclusion criteria: Recent (<6 months) participation in 2H2O tracer studiesCachexia (loss of 5% or more of body weight over the preceding 6 months)Score of 2 or more on the Malnutrition Universal Screening Tool (MUST) for adults or score of 1 on subitem 2, 3 and/or 4 of the STRONGkids Screening Tool for childrenInsulin dependent diabetes mellitusCo-morbidities and neuromuscular disorders of the lower limbs severely interacting with mobility with limited or no opportunity for improvement (e.g. cerebral palsy)Peripheral arterial disease Fontaine III or IVChronic obstructive pulmonary disease (COPD) GOLD III or IVUse of systemic steroids in the past four weeks, other than indicated for the specific type of surgeryUse anti-inflammatory biologicals (e.g. TNF-alfa blockers) in the past four weeksNeoadjuvant chemo- or radiotherapy in the past four weeksSurgical intervention in the past four weeksPregnancyAny other medication or (medical) condition that may interfere with the safety of the subjects or the outcome parameters, in the investigators judgementInvestigator’s uncertainty about the willingness or ability of the subject to comply with the protocol instructions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameters include daily protein synthesis rates and enrichments in a variety of organ tissues throughout the human body, including brain, heart, lung, liver, intestinal, hepatic and musculoskeletal tissues. | — |
Secondary
| Measure | Time frame |
|---|---|
| Niet van toepassing. | — |
Countries
Netherlands
Contacts
Public ContactL.J.C. van Loon
Universiteit Maastricht
Outcome results
None listed