Left ventricular dysfunction in multivessel coronary artery disease Reduced function of the left ventricle in patients with blockages in several coronary arteries.
Conditions
Interventions
CABG of all major coronary arteries vs PCI of all major coronary arteries.
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age > 18 yearsLVEF< 40%Angina pectoris, CCS>=2 and/or hospitalization for ACS or heart failure within 1 year prior to randomization Multivessel CAD (2-3 vessel-disease with coronary lesions >70% and involvement of proximal LAD, and/or LM stenosis of >50%)Clinical and angiographical characteristics suitable for isolated coronary revascularization both by CABG or PCI according to the judgment of the local Heart Team Written informed consent
Exclusion criteria
Exclusion criteria: ACS < 48 hours before randomization Valvular/structural heart disease requiring intervention Contra-indications to DAPT Non-cardiac condition with life expectancy < 1 year Previous CABG
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint will be the hierarchical composite of all-cause mortality, repeated major cardiovascular adverse events (MACE, including non-procedural myocardial infarction, stroke, unplanned revascularization) and repeated hospitalisations for heart failure at 4 years.. | — |
Secondary
| Measure | Time frame |
|---|---|
| A number of secondary endpoints are: a/ the individual components of the primary endpoint and MACE; b/ cardiovascular mortality; c/ periprocedural myocardial infarction; d/ target vessel (and lesion) revascularization; e/ (change in) Seattle Angina Questionnaire and KCCQ at 1 and 4 years, f/ cost-effectiveness analysis (calculated as QALY and ICER) | — |
Countries
Netherlands
Contacts
Public ContactE. Lipsic
Universitair Medisch Centrum Groningen
Outcome results
None listed