metabolic dysfunction-associated steatotic liver disease Fatty liver disease
Conditions
Interventions
gastrointestinal transit will be modulated by administration of a single dose of the challenge agents liraglutide 0.6 mg (= decreased gastric emptying) and erythromycin 250 mg (= increased gastric emp
 
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Participants are able to provide signed and dated written informed consent prior to any study specific proceduresUse of effective contraception (only applicable to premenopausal women; a pregnancy test will be performed in these women at baseline)Aged = 18 years
Exclusion criteria
Exclusion criteria: Not capable of being in a supine position for a longer period of timeClaustrophobia / metal implants or fragments (= contra-indication MRI)Intolerance for fructoseProlonged QTc interval (= contra-indication erythromycin)Use of QTc-prolonging medicationUse of medication metabolized by CYP3A4.History of delayed gastric emptying (e.g. postprandial nausea)Diabetes mellitusPregnancyPatients with congestive heart failure and/or severe renal and or liver insufficiency Uncontrolled hypertensionPrevious enrolment in a clinical study with an investigational product during the last 3 months or as judged by the investigator which would possibly hamper our study resultsUse of drugs that affect gastrointestinal motilityParticipants who do not want to be informed about unexpected medical findings
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intrahepatic fructose 1 phosphate load, as determined by the incremental area under the curve, quantified as phosphomonoester peaks (31P MRS) after oral administration of 60g fructose | — |
Secondary
| Measure | Time frame |
|---|---|
| urinary fructose, serum fructose and glycerate, and blood pressure response after oral administration of 60g fructose | — |
Countries
Netherlands
Contacts
Public ContactM.C.G.J. Brouwers
Maastricht Universitair Medisch Centrum +
Outcome results
None listed