Healthy adults Healthy adults
Conditions
Interventions
Participants will undergo simultaneous measurements of diaphragm SWE, transdiaphragmatic pressure (Pdi = Pga–Pes), and inspiratory mouth pressures (Pmo) at rest and during inspiratory efforts at 20%,
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 18–60 years, BMI 18–30 kg/m²No known respiratory, neuromuscular, or cardiothoracic diseaseAble to perform inspiratory maneuvers and consent.
Exclusion criteria
Exclusion criteria: PregnancyHistory of smoking (> 10 pack years)Impaired swallowing, as well as esophageal diseases, or disorders at the level of the gastroesophageal sphincterlatex allergy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility: SWE acquisition success: % attainable diaphragm SWE measurements (per condition: FRC apnea, 20/40/60% PImax). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary:Data completeness: % complete paired SWE–Pdi measurements.Inter-rater reliability: Inter-rater Correlation Coefficient (ICC) for SWE between ultrasound operators.Exploratory:Pearson correlation coefficient repeated-measures correlation coefficient between SWE and Pdi across inspiratory efforts within-individuals and overall. | — |
Countries
Netherlands
Contacts
Public ContactW.S. Boer
Universitair Medisch Centrum Groningen
Outcome results
None listed