Severity of paediatric acute respiratory distress syndrome

Effect of FiO2 and PEEP on PARDS severity strata distribution - Effect of FiO2 and PEEP on PARDS severity strata distribution

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON58446

Enrollment

Registered

2025-08-29

Start date

2026-02-02

Completion date

Unknown

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Paediatric acute respiratory distress syndrome Shock lung

Interventions

None listed

Eligibility

Age

No minimum to 17 Years

Inclusion criteria

Inclusion criteria: Meet PARDS criteria (per PALICC 2)Deeply sedated (i.e., unresponsive to verbal or tactile stimuli)On invasive mechanical ventilationHave an indwelling arterial line in situ

Exclusion criteria

Exclusion criteria: Uncorrected congenital heart disease with right-to-left shuntingSingle ventricle cardiac physiologyLife-threatening pulmonary hypertension

Design outcomes

Primary

Measure	Time frame
The main study endpoint is the distribution of PARDS severity strata (mild, moderate, severe) at baseline and at four different combinations of FiO2 and PEEP	—

Secondary

Measure	Time frame
Cardiac output,  end-tidal alveolar dead space fra	—

Countries

Netherlands

Contacts

Public ContactM.C.J. Kneyber

Universitair Medisch Centrum Groningen

m.c.j.kneyber@umcg.nl0031503614215

Outcome results