jointprosthesis infection, muscle mass loss, tissue protein turnover infection of a joint prosthesis, loss of muscle mass, tissue protein synthesis
Conditions
Interventions
Both male and female patients (n = 20, age: 50-80 y) with a PJI of the knee or hip that will be electively admitted to the hospital for debridement or one- or two stage revision surgery followed by in
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Written informed consentMentally competent, as judged by the treating physicianDiagnosed with a periprostethic joint infection of hip or knee jointScheduled for surgery followed by intravenous antibiotic administrationAge between 50 - 80 years
Exclusion criteria
Exclusion criteria: Age <50 or >80 yearsBMI >35 kg/m2Cognitive disorders that influence good understanding of the study proceduresNeurological or physical disorders, apart from the PJI of hip or knee joint, that influence habitual physical activity. ICU or MCU admission after surgeryChronic diseases that influence muscle metabolism: COPD Gold IV, Heart Failure NYA III-IV, thyroid disorders.Peripheral Artery Disease Fontaine III en IVUse of corticosteroids, thyroid medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determine the changes in Quadriceps muscle CSA during hospitalization in patients with a PJI of the hip or knee joint. | — |
Secondary
| Measure | Time frame |
|---|---|
| Determine changes in muscle strength during hospitalization in patients with a PJI of the hip or knee joint.Determine changes in whole-body lean mass and fat mass during hospitalization in patients with a PJI of the hip or knee joint.Determine changes in physical activity level during hospitalization in patients with a PJI of the hip or knee joint.Determine changes in dietary energy and protein intake during hospitalization in patients with a PJI of the hip or knee joint. | — |
Countries
Netherlands
Contacts
Public ContactM Beelen
Universiteit Maastricht
Outcome results
None listed