stress stress
Conditions
Interventions
The intervention in this study is daily life stress. Participants will also undergo a Trier social stress test (TSST), performed using a VR-device. The stress response will be determined by assessing
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Biologically male or female.BMI < 25 kg/m2European ethnicityFor women: using oral anticonception or having a hormonal intra-uterine device. Age from 20 to 40 years old.Capable of giving written informed consentWilling to visit the Erasmus MC at four subsequent days. In possession of smart phone and willing to download several apps. Being legally competent
Exclusion criteria
Exclusion criteria: Being pregnant (Auto-) immune disease(s) including diabetes type 1, adrenal disease, M. CushingUsing or having used corticosteroids (inhalation, tablets, creams or injections) in the past three monthsUse of antidiabetic medication. Abuse of alcohol or other substancesSmokingHaving a pacemaker or ICD (implantable cardioverter-defibrillator)Working irregularly (e.g. night shifts) Use anti-obesity drugs or underwent bariatric surgeryBeing involved in another clinical trialHaving a dependency relationship with the researchers (e.g. students from our department).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Which of the measured parameters are best to measure stress non-invasively in daily life and in response to a psychosocial stressor? I.e. which of the measured parameters correlate best to the gold standard (= continuously measured cortisol using microdialysis) in stress measurements and are well-tolerated by the participant? | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess whether possible alterations in diurnal cortisol levels are associated with continuously measured glucose levels . To assess the relationship between short-term cortisol levels (measured in interstitial fluid and saliva), glucocorticoid receptor sensitivity, and long-term cortisol levels in hair. To assess the relationship between cortisol rhythm and melatonin rhythm in interstitial fluid. | — |
Countries
Netherlands
Contacts
Public ContactJE Oosterman
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed