post-covid, post-sepsis, post-IC, post-acute infectious syndromes, PAIS post-COVID, post-sepsis, PAIS
Conditions
Interventions
Blood and CSF will be drawn. multi-omics will be performed on these biosamples and related to the cognitive and neuropsychiatric outcomes of these subjects.
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Our definition of the post-acute infectious syndrome (PAIS) here is as follows: at least one of the following subjective symptoms that newly developed and persist 3-6 months following acute inflammatory episode: anxiety, depression, sleep disorders, complaints in memory or concentration (including brain fog).
Exclusion criteria
Exclusion criteria: WilsonbekwaamheidContra-indications to a lumbar puncture, e.g. use of anti-coagulants, dual anti-platelets, local skin infection, bleeding disorderUse of immunosuppressive agents (we use an extensive list of drugs that fall in this category for similar studies and that we keep updating as new drugs are being introduced, see Table 4.3.A for current list)Previous infection within the brain compartment (meningitis, encephalitis)Acute illness resulting in brain damage (e.g. stroke, traumatic brain injury, etc) in the last two years or after the primary infection that led to PAISAlternative diagnoses that explain the neurocognitive complaintsNeuropsychiatric disorders that necessitated drug treatment (e.g. depression, psychosis) that were already present before the primary infection that led to PAISPre-existing (pre-infection) diagnosis of cognitive decline / mild cognitive impairment / dementiaKidney failure with dialysis need (as this is a large independent risk factor for cognitive decline)Severe reduced heart function (ejection fraction <30%) as this a large independent risk factor for cognitive declineBedridden or unable to travel to Radboudumc for the lumbar puncture
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biological neuroimmune pathways based on multiomics of the cerebrospinal fluid | — |
Secondary
| Measure | Time frame |
|---|---|
| Microbiome data in subjects with PAIS with and without cognitive deficitsBiomarker data related to PEMBiomarker profiles related to behavioral, lifestyle, mood, physical parameters such as mood disorder, sleep quality, physical activity, demographics | — |
Countries
Netherlands
Contacts
Public ContactW Abdo - Käyser
Radboud Universitair Medisch Centrum
Outcome results
None listed