Placenta accreta spectrum disease. Placenta growing too deeply into the uterus.
Conditions
Interventions
Not applicable.
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in the Predict study, a subject must meet all of the following criteria:- 18 years of age or older- Competent- Pregnancy <10 weeks (so that at least 2 of the 3 ultrasound examinations can take place in the first trimester)- Pregnancy up to 12 weeks (so that at least one ultrasound scan can take place in the first trimester, in week 11). This only applies to pGZ participants. Inclusion can be combined with participation in the virtual embryoscope, cell-free DNA, or PROMOTE sub-studies.- Willing to sign the consent form- Women who come to the outpatient clinic for medical preconception counseling and/or preconception counseling focused on nutrition and lifestyle (Polikliniek Gezond Zwanger (PGZ)) or- Women who come to one of the outpatient clinics of the Obstetrics & Gynecology department for a pregnancy check-up or prenatal diagnostics or- women who are admitted with suspected fetal growth restriction and/or preeclampsia, congenital abnormalities and/or premature birth and/or twin pregnancy, or- women who give birth or have given birth at Erasmus MC / Sophia Birth Center. In order to be eligible to participate in this study, a subject from the Predict studie must meet also all of the following criteria:Cases: pregnant people with a history of =1 caesarean section (all cases available from dataset; estimated at 30-40).Controls: parity matched pregnant people without a history of uterine surgery.Gestational age <13 weeks at time of first ultrasound.The case/control ratio is 1:2.
Exclusion criteria
Exclusion criteria: <18 years of age at time of inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ultrasound measurements: parameters will be used or determined using images from ultrasound scans taken in the first trimester. Doppler art uterina; placental vascular volume (PVV); uterine vascular volume (UVV); gestational sac volume; placental volume; placental thickness and length (where available). | — |
Secondary
| Measure | Time frame |
|---|---|
| Ultrasound measurements: parameters will be used or determined using images from ultrasound scans taken in the first trimester.All cases: gestational sac distance from midline; placental location; placental distance to os internum cervix; placental maximum thickness; umbilical cord insertion; myometrium (thinnest part); decidua thickness (caudal to GS); position uterusCases with a history of =1 caesarean section: niche length, height and width (when applicable), distance scar to os internum cervix; distance scar to gestational sac (midpoint and caudal edge); distance placenta (caudal point) to scar; decidua width over scar/niche; first trimester PAS signs of COS sign, GS relation to midline, and implantation of GS in relation to the scar (as described in “First trimester prediction of placenta accreta spectrum disease (PAS) using ultrasonic markers: feasibility study”) | — |
Countries
Netherlands
Contacts
Public ContactA.G.M.G.J. Mulders
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed