Chronic oncological pain, PSPS-T2, nociplastic pain, nociceptive pain Pain
Conditions
Interventions
Not applicable.
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a participant must meet all of the following criteria:Age =18 years.Clinical diagnosis of chronic oncological pain (=3 months duration) or persistent spinal pain syndrome type 2 (PSPS2).Ability to provide written informed consent.
Exclusion criteria
Exclusion criteria: A potential participant who meets any of the following criteria will be excluded from participation in this study:Presence of known brain lesions.Presence of neuropsychiatric comorbidities (i.e., major depression, anxiety disorder, Alzheimer’s disease, Parkinson’s disease, migraine).General contraindications to 7T MRI (non 7T MRI conditional metal implants, claustrophobia, etc.).Inability to come to the scanning facility at UMC Utrecht, Utrecht, The Netherlands
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoints: Metabolic imaging measures of glutamate, N-acetylaspartate, choline, creatine and other molecules of interest. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints: (1) Differences in metabolic profiles between oncological vs. non-oncological pain; (2) Correlations between imaging parameters and pain intensity/impact (McGill Pain Questionnaire). | — |
Countries
Netherlands
Contacts
Public ContactDJHA Henssen
Radboud Universiteit Nijmegen
Outcome results
None listed