Hereditary spastic paraplegia
Conditions
Interventions
Participants in the intervention group will train three times a week in the home setting or unsupervised community setting (e.g. fitness centre) . During the training, the following constructs will be
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adults with a diagnosis of pure HSP by a neurologist specialized in inherited movement disorders. Diagnosis is based clinical examination, and when available, on inheritance pattern and molecular diagnosis.Being able to walk for 6 minutes (the use of a walking aid is allowed)Mini Balance Evaluations Systems Test (MiniBESTest) between 8 and 24 pointsReceiving a stable treatment regimen for at least 3 months prior to inclusion, without initiation of new physical therapy or other interventions that could influence balance or gait performance.
Exclusion criteria
Exclusion criteria: Presence of other neurological, orthopaedic, or psychiatric conditions impacting balance and gait, or the ability to follow instructions.Participation in = 3 sessions per week of (un)supervised functional training and/or vigorous aerobic exercise training.Is currently receiving functional training from their own primary care physiotherapist, and is unwilling to substitute this with the study-specific training delivered by the study physiotherapist for the duration of the study.Poorly controlled or unstable cardiovascular disease, according to the American Heart Association (AHA) guidelinesRespiratory problems that preclude participation in aerobic fitness training, according to the American Heart Association (AHA) guidelinesIs participating in another intervention trial during the course of the current study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is balance and gait capacity, as measured with the MiniBESTest. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcomes include:Cardiorespiratory fitness, as measured with a maximal exercise test with breath-by-breath gas analysis.Relative load of walking, as measured with breath-by-breath gas analysis during 6-minutes of walking.Balance confidence, as measured by the Activities-specific Balance Confidence Scale (ABC)Disease severity, as measured by the Spastic Paraplegia Rating Scale (SPRS)Quality of life, as measured by SF-36Levels of daily physical activity, as measured with an activity monitorFatigue, as measured by the Fatigue Severity Scale (FSS)Walking speed, as measured by the 10 Meter Walk Test (10MWT) | — |
Countries
Netherlands
Contacts
Public ContactN Kikstra
Radboud Universitair Medisch Centrum
Outcome results
None listed