Multiple Sclerosis Multiple Sclerosis
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All people with multiple sclerosis and all controls who have previously participated in the “Amsterdam MS Cohort” (2020/269) and have provided interest in being contacted for follow-up study.
Exclusion criteria
Exclusion criteria: General exclusion criteria:PregnancyKnown contraindications for MRI investigations, such as the presence of metal objects (e.g., pacemaker, arteriovenous clips) or severe claustrophobia.A neurological disorder other than multiple sclerosisIncapable of providing informed consent independentlyAdditional exclusion criteria for people with multiple sclerosisA relapse in the two months prior to participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are brain network dynamics measured by mw-fMRI, cognitive performance quantified by extensively validated tests, and the impact on daily life determined by ecological sampling. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objectives explore how naturalistic measurements in people with multiple sclerosis (PwMS) relate to laboratory-based assessments. This includes: investigating the added value of mw-fMRI compared with rs-fMRI and establishing how fluctuations in mood, stress, and affect in daily life compare to questionnaires. | — |
Countries
Netherlands
Contacts
Public ContactT. A. A. Broeders
Amsterdam UMC
Outcome results
None listed