Trapeziometacarpal (TMC) joint osteoarthritis / fist carpometacarpal (CMC-1) joint osteoarthritis / thumb base joint osteoarthritis Thumb base joint osteoarthritis
Conditions
Interventions
The study will include 30 patients aged 18 years and older with a clinical suspicion of TMC OA. All patients will undergo a bilateral 3D CT scan in neutral wrist position and bilateral dynamic 4DCT sc
scanning, patients will be instructed to actively perform two continuous and homogeneous thumb movements: adduction-abduction and opposition-reposition. Patients will move their thumb from maximal abd
range of motion during adduction–abduction (<
45 degrees)  
or opposition–reposition (<
6 Kapandji grade) will be excluded to ensure high-quality movement analysis. Pain and symptom severity will be documented using the Patient Rated Wrist/Hand Evaluation (PRWHE) questionnaire, expressed
In addition, participants will rate pain during unloaded abduction–adduction and opposition–reposition movements using the same NRS scores.
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: > 18 years old Clinical suspicion of unilateral or bilateral TMC OAPatients should be able to perform the required motion protocol with a continuous movement, defined as:Thumb abduction–adduction–abduction movement within 4 seconds, with a minimum range of motion = 45 degrees Thumb neutral–opposition–neutral movement within 7 seconds, with a minimum Kapandji grade = 6 Clear understanding of the Dutch languageInformed consent from the patient
Exclusion criteria
Exclusion criteria: Medical history of trauma, chronic pain, or surgery involving the thumb (left and right)Diagnosis or clinical suspicion of inflammatory arthritis (rheumatoid)Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main endpoint: investigate the partaking bones of the TMC joint and their movement. The 4DCT parameters to be measured are the proximity pattern and contact recurrence pattern.Furthermore, correlations between reported pain and function scores and deviations in dynamic proximity and contact recurrence patterns of patients with symptomatic TMC OA will be evaluated. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Contacts
Public ContactR.M. Dekkers
Radboud Universitair Medisch Centrum
Outcome results
None listed