Obesity Obesity
Conditions
Interventions
Patients will undergo metabolic and adipose tissue assessments before and after surgery. To this end, adipose tissue biopsies and blood samples will be collected before the preoperative low-calorie di
Sponsors
Catharina Ziekenhuis
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: BMI >40 kg/m2 or >35 kg/m2 with obesity-related complicationsEligible for bariatric surgery after MDT screeningPrimary gastric bypass (RY,RA) as the chosen procedureWilling to provide adipose tissue biopsies and blood samples
Exclusion criteria
Exclusion criteria: Severe uncontrolled metabolic disordersPrevious bariatric surgeryOther than primary gastric bypass procedurePregnant or lactating women, or planning to become pregnant within first 2 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patients will be stratified into two groups based on the Fibrosis in Adipose Tissue (FAT) score (low fibrosis, FAT-score <2; high fibrosis, FAT-score =2). The primary outcome is body weight change 2 years after metabolic/bariatric surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in cardiometabolic risk factors, evolution of obesity complications and level of fibrosis post-bariatric surgery will also be examined. | — |
Countries
Netherlands
Contacts
Public ContactSW Nienhuijs
Catharina Ziekenhuis
Outcome results
None listed