Acute Respiratory Distress Syndrome Shock lung, sudden severe lung failure
Conditions
Interventions
Ventilation with both PCV and APRV as part of standard care.
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Mechanical ventilated with both PCV and APRV modes and Airway Pressure Release Ventilation (APRV) as part of routine clinical care and availability of routinely collected pressure and flow data during the transition from PCV to APRV.Informed consent.
Exclusion criteria
Exclusion criteria: Presence of pneumothorax or subcutaneous emphysema during the relevant ventilation periods. -Extreme obesity (BMI > 40 kg/m²).Severe hemodynamic instability, defined as norepinephrine > 0.5 µg/kg/min during the ventilation period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in mean mechanical power over 10 consecutive breaths (expressed in joules/min) between PCV and APRV based on available clinical measurements during both ventilation modes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ventilator settings for PCV and APRV, relevant respiratory variables and blood gases, such as P/F ratio, PaCO2, minute ventilation and dynamic respiratory system compliance. | — |
Countries
Netherlands
Contacts
Public ContactJ.P. Oosten
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed