rheumatoid arthritis, early arthritis, inflammatory arthritis arthritis
Conditions
Interventions
Patients with early arthritis aged =18 and who consent with the BioBank “Reumatische Klachten in the LUMC (locally also known as Early Arthritis Clinic (EAC)
running since 1993) will be asked to undergo this non-invasive portable MRI at baseline. Inclusion of patients will continue until a total sample size at baseline of 546 patients is reached. Follow-up
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria for this study are similar to the inclusion criteria for the EAC/Biobank “Reumatische Klachten”, namely Patients aged =18 years with presence of synovitis determined at physical examination by a rheumatologist and a symptom duration <2 years.
Exclusion criteria
Exclusion criteria: An obvious diagnosis of gout or osteoarthritisDespite of the low field strength, people with pacemakers or specific metal implants cannot participate. Also women who might be pregnant cannot participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main endpoint is the absence of persistent inflammatory arthritis, defined as either the absence of persistent clinical arthritis without having started DMARD therapy, or in case DMARD therapy was initiated, the development of sustained DMARD-free remission, defined as the persistent absence of clinical arthritis after DMARD cessation with a minimal follow-up duration of 1 year after DMARD stop. | — |
Secondary
| Measure | Time frame |
|---|---|
| Additionally to the outcome described above, we will also assess the amount of patients fulfilling the 2010 RA classification criteria after 1 year of follow-up. | — |
Countries
Netherlands
Contacts
Public ContactA.H.M. van der Helm-van Mil
Leids Universitair Medisch Centrum
Outcome results
None listed