endometrial cancer uterine cancer
Conditions
Interventions
The composition of the vaginal microbiome in women with Lynch syndrome and whether this differs from that of women without Lynch syndrome—with and without endometrial cancer.
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: A. Lynch carriersInclusion criteriaMentally competent women with proven Lynch mutation under surveillance at Radboudumc; Age 40 – 60 years.B. Non-Lynch carriersInclusion criteriaMentally competent women approached by a proven Lynch mutation carrier under surveillance in Radboudumc; Age 35 – 65 years (wider age interval due to the five-year age range).C. Patients with endometrial cancerInclusion criteriaMentally competent women with non-Lynch endometrial cancer in Radboudumc, Canisius Wilhelmina Ziekenhuis or Rijnstate undergoing hysterectomyAge 40 – 75 years
Exclusion criteria
Exclusion criteria: A. Lynch carriersExclusion criteriaHysterectomy;Current pregnancy.B. Non-Lynch carriersExclusion criteriaHysterectomy;Current pregnancy.C. Patients with endometrial cancerExclusion criteriaPrior hysterectomy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The composition of the vaginal microbiome in women with Lynch syndrome in terms of diversity, relative abundance, and relative contribution of Lactobacillus compared to healthy women of the same age. | — |
Secondary
| Measure | Time frame |
|---|---|
| The stability of the vaginal microbiome over a period of time (4 months).A comparison of the vaginal microbiome between women with/without Lynch syndrome without endometrial cancer and those with non-Lynch-related endometrial cancer. | — |
Countries
Netherlands
Contacts
Public ContactKJJ Kwinten
Radboud Universitair Medisch Centrum
Outcome results
None listed