Colorectal cancer, bowel cancer, CRC bowel cancer
Conditions
Interventions
All participating individuals will receive a FIT (FOB Gold® Wide, Sentinel Diagnostics, Italy) by postal mail. The patient is asked to return the FIT by mail to NKI-AVL, where FIT analyses will be per
Sponsors
Antoni van Leeuwenhoek (AVL)
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All symptomatic individuals =18 years referred by their general practitioner for colonoscopy
Exclusion criteria
Exclusion criteria: A potential participant who meets any of the following criteria will be excluded from participation in this study:Unable or unwilling to provide informed consent.Medical conditions that make participation inappropriate or unsafe, such as:Terminal illness.Significant cognitive impairment or severe psychiatric conditions affecting decision-making or compliance with study procedures.Referral for colonoscopy surveillance (i.e. for colorectal cancer, post-polypectomy surveillance, familial CRC, hereditary cancer syndromes, IBD surveillance)Individuals with recent severe rectal bleeding (i.e. within the last 48 hours) or other acute gastrointestinal emergencies that require immediate diagnostic evaluation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity of FIT-based referral for colorectal cancer | — |
Secondary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy for advanced colorectal neoplasia of ColonAiQ-based referral, shown as Area Under the Curve (AUC) of the Receiver Operating Characteristic (ROC) curveDiagnostic accuracy for IBD of symptom-, FIT-, and ColonAiQ-based referral, shown as AUC of the ROC curveDiagnostic accuracy for advanced colorectal neoplasia of the NICE criteria, shown as AUC of the ROC curveReduction in performed colonoscopies by implementation of FIT as a triage test, assessed using a health assessment model | — |
Countries
Netherlands
Contacts
Public ContactJQ Ginkel
Antoni van Leeuwenhoek (AVL)
Outcome results
None listed