Descending Aortic Dissection
Conditions
Interventions
Digital Twin Computational Model, based on CTA and 4D flow MRI imaging. A fluid-structure interaction model of the aortic wall, intimal flap and true and false lumen will be used as computational mode
Sponsors
Rijnstate
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Uncomplicated Type B Dissection in the past 2 weeksAged 18 years or older at the time of informed consent signature
Exclusion criteria
Exclusion criteria: Participants with no signed informed consentScheduled surgical or endovascular treatment of Type B DissectionParticipants previously treated in their descending aorta, either open surgery or TEVARSeverely impaired renal function (eGFR < 30mL/min/1.74m2)Participants with traumatic aortic dissectionsParticipants with an established connective tissue disease, including but not limited to Marfans and Loeys-Dietz syndromePregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite outcome of positive false lumen development: full thrombosis of the false lumen, or no false lumen diameter growth over 3-mm per year during one year follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life and physical and mental health status during 1-year follow-upPercentage of thrombosed false lumen during 1-year follow-upChange in volume of the false lumen during 1-year follow-upChange in maximal descending aortic diameter during 1-year follow-upChange in descending aortic volume during 1-year follow-upAortic-related mortality, hospital readmission, organ malperfusion, TEVAR | — |
Countries
Netherlands
Contacts
Public ContactL Velde
Rijnstate
Outcome results
None listed