Critical illness Critical illness
Conditions
Interventions
One group of patients received proteins based on ABW (Actual Body Weight) until July 2023, and a second group was based on FFM (Fat-Free Mass). No intervention, only standard care. 
Sponsors
Ziekenhuis Gelderse Vallei
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients meeting all of the following criteria are eligible for the study: 1. Age = 18 years 2. A BIA measurement within 48 hours after ICU admission 3. Two BIA measurements during ICU stay
Exclusion criteria
Exclusion criteria: Any patient meeting one or more of the following criteria is not eligible for the study: 1. Transfer from another ICU resulting in the first BIA measurement >48 hours after admission to Gelderse Vallei Hospital 2. A previous ICU admission within 2 weeks before the current admission 3. Contra-indications for BIA measurement: i. Patients with electrical implants such as a pacemaker or ICD ii. Patients who cannot maintain posture for the (5 min) duration of the measurement iii. Patients with wounds or skin damage in the designated electrode sight iv. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary: The primary outcome measure of this study is mortality, comparing patients who received protein based on actual body weight with those who received protein based on fat-free mass. Mortality will be assessed as both short-term mortality (ICU and 30-day mortality) and long-term mortality (90-day mortality). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary: Secondary outcome measures include several clinical and nutritional endpoints, all comparing the cohort receiving protein based on actual body weight with the cohort receiving protein based on fatfree mass: • ICU and hospital length of stay, defined as the total duration of ICU and hospital admission in days, measured from ICU admission until discharge. • Duration of invasive mechanical ventilation (IMV), defined as the number of days a patient receives IMV from initiation until discontinuation. • Urea–creatinine ratio (UCR) during ICU stay, comparing differences in UCR between both groups throughout the ICU stay. • Changes in BIA parameters over time, including changes in fat-free mass and other body composition measures, based on repeated bioelectrical impedance analysis (BIA) measurements during ICU stay. • Protein and energy intake during ICU stay, comparing daily and cumulative (first 14 days) protein and energy intake between the two groups. | — |
Countries
Netherlands
Contacts
Public ContactMC Paulus
Ziekenhuis Gelderse Vallei
Outcome results
None listed