Parkinson's, Parkinson's Disease, PD, saliva, xerostomia, hyposialia, hypersialia, sialorrhea, dysphagia Parkinson, Parkinson's disease, saliva, spit, dry mouth, drooling, loss of saliva, swallowing problems
Conditions
Interventions
Chewing gum: chewing for 60 seconds in order to measure chewing ability.Collect saliva in a cup: 1 x 5 minutes unstimulated and 1x 5 minutes stimulated by chewing on a 5x5cm piece of parafilm. 
Sniffin’ Stick Test: to measure olfactory dysfunction. Participants are asked to smell a ‘stick’ which is offered once and identify the scent by choosing from four options.Taste strips: tasting to mea
Sponsors
Academisch Centrum Tandheelkunde Amsterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Observational group: - Diagnosis PD - Score van = 19 of the MOCA of RUDAS Control group: - age- and sex matched healthy controls
Exclusion criteria
Exclusion criteria: Observational group: - People with atypical forms of parkinsonism, such as Multiple System Atrophy (MSA) and Progressive Supranuclear Palsy (PSP) - Treated in the past with chemotherapy or radiation therapy in the head and/or neck-region - Diabetes Mellitus or Sjogren’s syndromeControl group: - Blood relatives with PD - Treated in the past with chemotherapy or radiation therapy in the head and/or neck-region - Diabetes Mellitus or Sjogren’s syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary parameters include subjective salivary experience (xerostomia, salivary loss, and swallowing difficulties) and objective measures of salivary secretion rate (stimulated and unstimulated). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters comprise unstimulated and stimulated salivary secretion rate, pH and buffered pH of (un)stimulated saliva, spinnbarkeit, mucin5B concentration, amylase concentration, and electrolyte composition. | — |
Countries
Netherlands
Contacts
Public ContactB.D.M. Dijk
Academisch Centrum Tandheelkunde Amsterdam
Outcome results
None listed