Kidney Kidney
Conditions
Interventions
dialysis
Sponsors
Rijnstate
Eligibility
Inclusion criteria
Inclusion criteria: Patients at Rijnstate Hospital scheduled to initiate kidney replacement therapy (defined as the start of the dialysis preparation pathway as determined by the treating nephrologist, with an estimated clearance <20 mL/min), including both hemodialysis and peritoneal dialysis.Age = 65 years.
Exclusion criteria
Exclusion criteria: Patients for whom a conservative (non–kidney replacement therapy) treatment approach has been established.Patients requiring short-term dialysis for acute kidney injury (e.g., temporary bridging on the intensive care unit).Inability to provide informed consent for study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Endpoints: Identification of predictors associated with a more rapid decline in frailty (assessed using the Clinical Frailty Scale) and cognitive function (assessed using the MoCA score). To this end, the baseline CFS and MoCA scores will be compared with the last available scores prior to study discontinuation (e.g., death, cessation of dialysis, loss to follow-up, etc.). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary Outcomes:Analysis of predictors of frailty according to the Fried criteria.Mortality at predefined time points.Number of unplanned hospital admissions at predefined endpoints, categorized as dialysis-related or non–dialysis-related.Discontinuation of dialysis (initiated by the patient or the treating nephrologist). | — |
Countries
Netherlands
Contacts
Public ContactM.L.M. van Riswijk
Rijnstate
Outcome results
None listed